CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer
CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer
About this item
Full title
Author / Creator
Weiskopf, Kipp , Jahchan, Nadine S. , Schnorr, Peter J. , Cristea, Sandra , Ring, Aaron M. , Maute, Roy L. , Volkmer, Anne K. , Volkmer, Jens-Peter , Liu, Jie , Lim, Jing Shan , Yang, Dian , Seitz, Garrett , Nguyen, Thuyen , Wu, Di , Jude, Kevin , Guerston, Heather , Barkal, Amira , Trapani, Francesca , George, Julie , Poirier, John T. , Gardner, Eric E. , Miles, Linde A. , de Stanchina, Elisa , Lofgren, Shane M. , Vogel, Hannes , Winslow, Monte M. , Dive, Caroline , Thomas, Roman K. , Rudin, Charles M. , van de Rijn, Matt , Majeti, Ravindra , Garcia, K. Christopher , Weissman, Irving L. and Sage, Julien
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
Small-cell lung cancer (SCLC) is a highly aggressive subtype of lung cancer with limited treatment options. CD47 is a cell-surface molecule that promotes immune evasion by engaging signal-regulatory protein alpha (SIRPα), which serves as an inhibitory receptor on macrophages. Here, we found that CD47 is highly expressed on the surface of human SCLC...
Alternative Titles
Full title
CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer
Authors, Artists and Contributors
Author / Creator
Jahchan, Nadine S.
Schnorr, Peter J.
Cristea, Sandra
Ring, Aaron M.
Maute, Roy L.
Volkmer, Anne K.
Volkmer, Jens-Peter
Liu, Jie
Lim, Jing Shan
Yang, Dian
Seitz, Garrett
Nguyen, Thuyen
Wu, Di
Jude, Kevin
Guerston, Heather
Barkal, Amira
Trapani, Francesca
George, Julie
Poirier, John T.
Gardner, Eric E.
Miles, Linde A.
de Stanchina, Elisa
Lofgren, Shane M.
Vogel, Hannes
Winslow, Monte M.
Dive, Caroline
Thomas, Roman K.
Rudin, Charles M.
van de Rijn, Matt
Majeti, Ravindra
Garcia, K. Christopher
Weissman, Irving L.
Sage, Julien
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4922696
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4922696
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI81603
