Increased mitochondrial arginine metabolism supports bioenergetics in asthma
Increased mitochondrial arginine metabolism supports bioenergetics in asthma
About this item
Full title
Author / Creator
Xu, Weiling , Ghosh, Sudakshina , Comhair, Suzy A A , Asosingh, Kewal , Janocha, Allison J , Mavrakis, Deloris A , Bennett, Carole D , Gruca, Lourdes L , Graham, Brian B , Queisser, Kimberly A , Kao, Christina C , Wedes, Samuel H , Petrich, John M , Tuder, Rubin M , Kalhan, Satish C and Erzurum, Serpil C
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
High levels of arginine metabolizing enzymes, including inducible nitric oxide synthase (iNOS) and arginase (ARG), are typical in asthmatic airway epithelium; however, little is known about the metabolic effects of enhanced arginine flux in asthma. Here, we demonstrated that increased metabolism sustains arginine availability in asthmatic airway ep...
Alternative Titles
Full title
Increased mitochondrial arginine metabolism supports bioenergetics in asthma
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4922712
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4922712
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI82925
