Rho Kinase Inhibition Is Essential During In Vitro Neurogenesis and Promotes Phenotypic Rescue of Hu...
Rho Kinase Inhibition Is Essential During In Vitro Neurogenesis and Promotes Phenotypic Rescue of Human Induced Pluripotent Stem Cell‐Derived Neurons With Oligophrenin‐1 Loss of Function
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Durham, NC, USA: AlphaMed Press
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English
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Durham, NC, USA: AlphaMed Press
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This study showed the morphological, biochemical, and functional features of human OPHN1‐deficient induced pluripotent stem cells characterized by hyperactive rho kinase (ROCK) signaling and their rescue by treatment with the ROCK inhibitor fasudil. These findings shed light on the relevance of the ROCK pathway during in vitro neuronal differentiat...
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Full title
Rho Kinase Inhibition Is Essential During In Vitro Neurogenesis and Promotes Phenotypic Rescue of Human Induced Pluripotent Stem Cell‐Derived Neurons With Oligophrenin‐1 Loss of Function
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4922854
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4922854
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ISSN
2157-6564
E-ISSN
2157-6580
DOI
10.5966/sctm.2015-0303
