Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape
Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape
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Author / Creator
Lu, Chao , Jain, Siddhant U. , Hoelper, Dominik , Bechet, Denise , Molden, Rosalynn C. , Ran, Leili , Murphy, Devan , Venneti, Sriram , Hameed, Meera , Pawel, Bruce R. , Wunder, Jay S. , Dickson, Brendan C. , Lundgren, Stefan M. , Jani, Krupa S. , De Jay, Nicolas , Papillon-Cavanagh, Simon , Andrulis, Irene L. , Sawyer, Sarah L. , Grynspan, David , Turcotte, Robert E. , Nadaf, Javad , Fahiminiyah, Somayyeh , Muir, Tom W. , Majewski, Jacek , Thompson, Craig B. , Chi, Ping , Garcia, Benjamin A. , Allis, C. David , Jabado, Nada and Lewis, Peter W.
Publisher
United States: American Association for the Advancement of Science
Journal title
Language
English
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Publication information
Publisher
United States: American Association for the Advancement of Science
Subjects
More information
Scope and Contents
Contents
Several types of pediatric cancers reportedly contain high-frequency missense mutations in histone H3, yet the underlying oncogenic mechanism remains poorly characterized. Here we report that the H3 lysine 36–to–methionine (H3K36M) mutation impairs the differentiation of mesenchymal progenitor cells and generates undifferentiated sarcoma in vivo. H...
Alternative Titles
Full title
Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape
Authors, Artists and Contributors
Author / Creator
Jain, Siddhant U.
Hoelper, Dominik
Bechet, Denise
Molden, Rosalynn C.
Ran, Leili
Murphy, Devan
Venneti, Sriram
Hameed, Meera
Pawel, Bruce R.
Wunder, Jay S.
Dickson, Brendan C.
Lundgren, Stefan M.
Jani, Krupa S.
De Jay, Nicolas
Papillon-Cavanagh, Simon
Andrulis, Irene L.
Sawyer, Sarah L.
Grynspan, David
Turcotte, Robert E.
Nadaf, Javad
Fahiminiyah, Somayyeh
Muir, Tom W.
Majewski, Jacek
Thompson, Craig B.
Chi, Ping
Garcia, Benjamin A.
Allis, C. David
Jabado, Nada
Lewis, Peter W.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4928577
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4928577
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aac7272
