Copper regulates cyclic-AMP-dependent lipolysis
Copper regulates cyclic-AMP-dependent lipolysis
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Author / Creator
Krishnamoorthy, Lakshmi , Cotruvo, Joseph A , Chan, Jefferson , Kaluarachchi, Harini , Muchenditsi, Abigael , Pendyala, Venkata S , Jia, Shang , Aron, Allegra T , Ackerman, Cheri M , Wal, Mark N Vander , Guan, Timothy , Smaga, Lukas P , Farhi, Samouil L , New, Elizabeth J , Lutsenko, Svetlana and Chang, Christopher J
Publisher
New York: Nature Publishing Group US
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English
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Publisher
New York: Nature Publishing Group US
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Contents
Biochemical analysis, and imaging using a copper-sensitive fluorescent sensor, demonstrate that copper regulates cAMP-mediated lipolysis by inhibiting the activity of the cAMP-degrading phosphodiesterase PDE3B.
Cell signaling relies extensively on dynamic pools of redox-inactive metal ions such as sodium, potassium, calcium and zinc, but their r...
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Full title
Copper regulates cyclic-AMP-dependent lipolysis
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4955676
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4955676
Other Identifiers
ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/nchembio.2098
