Hydrophobic CDR3 residues promote the development of self-reactive T cells
Hydrophobic CDR3 residues promote the development of self-reactive T cells
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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Through analyses of β-chain variable regions in self-reactive T cell antigen receptors, Huseby and colleagues show that an index based on the interfacial hydrophobicity of amino acids at positions 6 and 7 of the CDR3β segment distinguishes self-reactive T cell antigen receptors.
Studies of individual T cell antigen receptors (TCRs) have shed som...
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Full title
Hydrophobic CDR3 residues promote the development of self-reactive T cells
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4955740
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4955740
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ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/ni.3491
