Mosquito bite immunization with radiation-attenuated Plasmodium falciparum sporozoites: safety, tole...
Mosquito bite immunization with radiation-attenuated Plasmodium falciparum sporozoites: safety, tolerability, protective efficacy and humoral immunogenicity
About this item
Full title
Author / Creator
Hickey, Bradley W , Lumsden, Joanne M , Reyes, Sharina , Sedegah, Martha , Hollingdale, Michael R , Freilich, Daniel A , Luke, Thomas C , Charoenvit, Yupin , Goh, Lucy M , Berzins, Mara P , Bebris, Lolita , Sacci, Jr, John B , De La Vega, Patricia , Wang, Ruobing , Ganeshan, Harini , Abot, Esteban N , Carucci, Daniel J , Doolan, Denise L , Brice, Gary T , Kumar, Anita , Aguiar, Joao , Nutman, Thomas B , Leitman, Susan F , Hoffman, Stephen L , Epstein, Judith E and Richie, Thomas L
Publisher
England: BioMed Central Ltd
Journal title
Language
English
Formats
Publication information
Publisher
England: BioMed Central Ltd
Subjects
More information
Scope and Contents
Contents
In this phase 1 clinical trial, healthy adult, malaria-naïve subjects were immunized with radiation-attenuated Plasmodium falciparum sporozoites (PfRAS) by mosquito bite and then underwent controlled human malaria infection (CHMI). The PfRAS model for immunization against malaria had previously induced >90 % sterile protection against homologous CH...
Alternative Titles
Full title
Mosquito bite immunization with radiation-attenuated Plasmodium falciparum sporozoites: safety, tolerability, protective efficacy and humoral immunogenicity
Authors, Artists and Contributors
Author / Creator
Lumsden, Joanne M
Reyes, Sharina
Sedegah, Martha
Hollingdale, Michael R
Freilich, Daniel A
Luke, Thomas C
Charoenvit, Yupin
Goh, Lucy M
Berzins, Mara P
Bebris, Lolita
Sacci, Jr, John B
De La Vega, Patricia
Wang, Ruobing
Ganeshan, Harini
Abot, Esteban N
Carucci, Daniel J
Doolan, Denise L
Brice, Gary T
Kumar, Anita
Aguiar, Joao
Nutman, Thomas B
Leitman, Susan F
Hoffman, Stephen L
Epstein, Judith E
Richie, Thomas L
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4957371
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4957371
Other Identifiers
ISSN
1475-2875
E-ISSN
1475-2875
DOI
10.1186/s12936-016-1435-y
