Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based...
Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma
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Author / Creator
Mazur, Pawel K , Herner, Alexander , Mello, Stephano S , Wirth, Matthias , Hausmann, Simone , Sánchez-Rivera, Francisco J , Lofgren, Shane M , Kuschma, Timo , Hahn, Stephan A , Vangala, Deepak , Trajkovic-Arsic, Marija , Gupta, Aayush , Heid, Irina , Noël, Peter B , Braren, Rickmer , Erkan, Mert , Kleeff, Jörg , Sipos, Bence , Sayles, Leanne C , Heikenwalder, Mathias , Heßmann, Elisabeth , Ellenrieder, Volker , Esposito, Irene , Jacks, Tyler , Bradner, James E , Khatri, Purvesh , Sweet-Cordero, E Alejandro , Attardi, Laura D , Schmid, Roland M , Schneider, Guenter , Sage, Julien and Siveke, Jens T
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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More information
Scope and Contents
Contents
The bromodomain and extraterminal (BET) inhibitor JQ1 synergizes with the histone deacetylase inhibitor SAHA to suppress tumor growth in mouse models of pancreatic cancer.
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human cancers and shows resistance to any therapeutic strategy used. Here we tested small-molecule inhibitors...
Alternative Titles
Full title
Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma
Authors, Artists and Contributors
Author / Creator
Herner, Alexander
Mello, Stephano S
Wirth, Matthias
Hausmann, Simone
Sánchez-Rivera, Francisco J
Lofgren, Shane M
Kuschma, Timo
Hahn, Stephan A
Vangala, Deepak
Trajkovic-Arsic, Marija
Gupta, Aayush
Heid, Irina
Noël, Peter B
Braren, Rickmer
Erkan, Mert
Kleeff, Jörg
Sipos, Bence
Sayles, Leanne C
Heikenwalder, Mathias
Heßmann, Elisabeth
Ellenrieder, Volker
Esposito, Irene
Jacks, Tyler
Bradner, James E
Khatri, Purvesh
Sweet-Cordero, E Alejandro
Attardi, Laura D
Schmid, Roland M
Schneider, Guenter
Sage, Julien
Siveke, Jens T
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4959788
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4959788
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.3952
