Structural basis for sulfation-dependent self-glycan recognition by the human immune-inhibitory rece...
Structural basis for sulfation-dependent self-glycan recognition by the human immune-inhibitory receptor Siglec-8
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Siglec-8 is a human immune-inhibitory receptor that, when engaged by specific self-glycans, triggers eosinophil apoptosis and inhibits mast cell degranulation, providing an endogenous mechanism to down-regulate immune responses of these central inflammatory effector cells. Here we used solution NMR spectroscopy to dissect the fine specificity of Si...
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Full title
Structural basis for sulfation-dependent self-glycan recognition by the human immune-inhibitory receptor Siglec-8
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4961179
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4961179
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1602214113
