Assignment of function to a domain of unknown function: DUF1537 is a new kinase family in catabolic...
Assignment of function to a domain of unknown function: DUF1537 is a new kinase family in catabolic pathways for acid sugars
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Author / Creator
Argonne National Laboratory (ANL), Argonne, IL (United States) , Zhang, Xinshuai , Carter, Michael S. , Vetting, Matthew W. , San Francisco, Brian , Zhao, Suwen , Al-Obaidi, Nawar F. , Solbiati, Jose O. , Thiaville, Jennifer J. , de Crécy-Lagard, Valérie , Jacobson, Matthew P. , Almo, Steven C. and Gerlt, John A.
Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Using a large-scale “genomic enzymology” approach, we (i) assigned novel ATP-dependent four-carbon acid sugar kinase functions to members of the DUF1537 protein family (domain of unknown function; Pfam families PF07005 and PF17042) and (ii) discovered novel catabolic pathways for D-threonate, L-threonate, and D-erythronate. The experimentally deter...
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Full title
Assignment of function to a domain of unknown function: DUF1537 is a new kinase family in catabolic pathways for acid sugars
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4961189
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4961189
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1605546113
