Neuronal activity enhances tau propagation and tau pathology in vivo
Neuronal activity enhances tau propagation and tau pathology in vivo
About this item
Full title
Author / Creator
Wu, Jessica W , Hussaini, S Abid , Bastille, Isle M , Rodriguez, Gustavo A , Mrejeru, Ana , Rilett, Kelly , Sanders, David W , Cook, Casey , Fu, Hongjun , Boonen, Rick A C M , Herman, Mathieu , Nahmani, Eden , Emrani, Sheina , Figueroa, Y Helen , Diamond, Marc I , Clelland, Catherine L , Wray, Selina and Duff, Karen E
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The authors show that tau can be released by neurons and transferred to other neurons via the extracellular space. Moreover, they show that enhancing neuronal activity accelerates transneuronal tau propagation and exacerbates tau pathology.
Tau protein can transfer between neurons transneuronally and trans-synaptically, which is thought to expla...
Alternative Titles
Full title
Neuronal activity enhances tau propagation and tau pathology in vivo
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4961585
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4961585
Other Identifiers
ISSN
1097-6256
E-ISSN
1546-1726
DOI
10.1038/nn.4328
