Genome-wide association of multiple complex traits in outbred mice by ultra-low-coverage sequencing
Genome-wide association of multiple complex traits in outbred mice by ultra-low-coverage sequencing
About this item
Full title
Author / Creator
Nicod, Jérôme , Davies, Robert W , Cai, Na , Hassett, Carl , Goodstadt, Leo , Cosgrove, Cormac , Yee, Benjamin K , Lionikaite, Vikte , McIntyre, Rebecca E , Remme, Carol Ann , Lodder, Elisabeth M , Gregory, Jennifer S , Hough, Tertius , Joynson, Russell , Phelps, Hayley , Nell, Barbara , Rowe, Clare , Wood, Joe , Walling, Alison , Bopp, Nasrin , Bhomra, Amarjit , Hernandez-Pliego, Polinka , Callebert, Jacques , Aspden, Richard M , Talbot, Nick P , Robbins, Peter A , Harrison, Mark , Fray, Martin , Launay, Jean-Marie , Pinto, Yigal M , Blizard, David A , Bezzina, Connie R , Adams, David J , Franken, Paul , Weaver, Tom , Wells, Sara , Brown, Steve D M , Potter, Paul K , Klenerman, Paul , Lionikas, Arimantas , Mott, Richard and Flint, Jonathan
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Jonathan Flint, Richard Mott and colleagues employ low-coverage (0.15×) sequencing and their new imputation method STITCH to perform genome-wide association analysis for complex traits in an outbred mouse population. They find >250 QTLs for 92 phenotypes and obtain gene-level mapping resolution for around 20% of the loci.
Two bottlenecks impedin...
Alternative Titles
Full title
Genome-wide association of multiple complex traits in outbred mice by ultra-low-coverage sequencing
Authors, Artists and Contributors
Author / Creator
Davies, Robert W
Cai, Na
Hassett, Carl
Goodstadt, Leo
Cosgrove, Cormac
Yee, Benjamin K
Lionikaite, Vikte
McIntyre, Rebecca E
Remme, Carol Ann
Lodder, Elisabeth M
Gregory, Jennifer S
Hough, Tertius
Joynson, Russell
Phelps, Hayley
Nell, Barbara
Rowe, Clare
Wood, Joe
Walling, Alison
Bopp, Nasrin
Bhomra, Amarjit
Hernandez-Pliego, Polinka
Callebert, Jacques
Aspden, Richard M
Talbot, Nick P
Robbins, Peter A
Harrison, Mark
Fray, Martin
Launay, Jean-Marie
Pinto, Yigal M
Blizard, David A
Bezzina, Connie R
Adams, David J
Franken, Paul
Weaver, Tom
Wells, Sara
Brown, Steve D M
Potter, Paul K
Klenerman, Paul
Lionikas, Arimantas
Mott, Richard
Flint, Jonathan
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4966644
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4966644
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/ng.3595
