FANCD2 limits replication stress and genome instability in cells lacking BRCA2
FANCD2 limits replication stress and genome instability in cells lacking BRCA2
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Full title
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Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
Probing the synthetic lethal effect of FANCD2 deletion in BRCA2-deficient cells reveals independent roles of FANCD2 and BRCA2 in stabilizing stalled replication forks to maintain genome stability and promote cell survival.
The tumor suppressor BRCA2 plays a key role in genome integrity by promoting replication-fork stability and homologous recom...
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Full title
FANCD2 limits replication stress and genome instability in cells lacking BRCA2
Authors, Artists and Contributors
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4973888
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4973888
Other Identifiers
ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/nsmb.3252
