Human native kappa opioid receptor functions not predicted by recombinant receptors: Implications fo...
Human native kappa opioid receptor functions not predicted by recombinant receptors: Implications for drug design
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
If activation of recombinant G protein-coupled receptors in host cells (by drugs or other ligands) has predictive value, similar data must be obtained with native receptors naturally expressed in tissues. Using mouse and human recombinant κ opioid receptors transfected into a host cell, two selectively-acting compounds (ICI204448, asimadoline) equi...
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Full title
Human native kappa opioid receptor functions not predicted by recombinant receptors: Implications for drug design
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4974614
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4974614
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/srep30797
