AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation...
AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation
About this item
Full title
Author / Creator
Cianfanelli, Valentina , Fuoco, Claudia , Lorente, Mar , Salazar, Maria , Quondamatteo, Fabio , Gherardini, Pier Federico , De Zio, Daniela , Nazio, Francesca , Antonioli, Manuela , D’Orazio, Melania , Skobo, Tatjana , Bordi, Matteo , Rohde, Mikkel , Dalla Valle, Luisa , Helmer-Citterich, Manuela , Gretzmeier, Christine , Dengjel, Joern , Fimia, Gian Maria , Piacentini, Mauro , Di Bartolomeo, Sabrina , Velasco, Guillermo and Cecconi, Francesco
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Inhibition of a main regulator of cell metabolism, the protein kinase mTOR, induces autophagy and inhibits cell proliferation. However, the molecular pathways involved in the cross-talk between these two mTOR-dependent cell processes are largely unknown. Here we show that the scaffold protein AMBRA1, a member of the autophagy signalling network and...
Alternative Titles
Full title
AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation
Authors, Artists and Contributors
Author / Creator
Fuoco, Claudia
Lorente, Mar
Salazar, Maria
Quondamatteo, Fabio
Gherardini, Pier Federico
De Zio, Daniela
Nazio, Francesca
Antonioli, Manuela
D’Orazio, Melania
Skobo, Tatjana
Bordi, Matteo
Rohde, Mikkel
Dalla Valle, Luisa
Helmer-Citterich, Manuela
Gretzmeier, Christine
Dengjel, Joern
Fimia, Gian Maria
Piacentini, Mauro
Di Bartolomeo, Sabrina
Velasco, Guillermo
Cecconi, Francesco
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4976803
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4976803
Other Identifiers
ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/ncb3072
