Atomic-resolution structure of a disease-relevant Aβ(1–42) amyloid fibril
Atomic-resolution structure of a disease-relevant Aβ(1–42) amyloid fibril
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Publisher
United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
Amyloid-β (Aβ) is present in humans as a 39- to 42-amino acid residue metabolic product of the amyloid precursor protein. Although the two predominant forms, Aβ(1–40) and Aβ(1–42), differ in only two residues, they display different biophysical, biological, and clinical behavior. Aβ(1–42) is the more neurotoxic species, aggregates much faster, and...
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Full title
Atomic-resolution structure of a disease-relevant Aβ(1–42) amyloid fibril
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5003276
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5003276
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1600749113
