Editing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer
Editing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer
About this item
Full title
Author / Creator
Provasi, Elena , Genovese, Pietro , Lombardo, Angelo , Magnani, Zulma , Liu, Pei-Qi , Reik, Andreas , Chu, Victoria , Paschon, David E , Zhang, Lei , Kuball, Jurgen , Camisa, Barbara , Bondanza, Attilio , Casorati, Giulia , Ponzoni, Maurilio , Ciceri, Fabio , Bordignon, Claudio , Greenberg, Philip D , Holmes, Michael C , Gregory, Philip D , Naldini, Luigi and Bonini, Chiara
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Engineered T cells expressing a tumor antigen specific T cell receptor (TCR) have shown promise for cancer immunotherapy. However, the introduced TCR chains can pair with the endogenous TCR chains in T cells, and in mice, these mismatched TCRs can cause a lethal autoimmune reaction. Provasi
et al
. now show that they can eliminate expression...
Alternative Titles
Full title
Editing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer
Authors, Artists and Contributors
Author / Creator
Genovese, Pietro
Lombardo, Angelo
Magnani, Zulma
Liu, Pei-Qi
Reik, Andreas
Chu, Victoria
Paschon, David E
Zhang, Lei
Kuball, Jurgen
Camisa, Barbara
Bondanza, Attilio
Casorati, Giulia
Ponzoni, Maurilio
Ciceri, Fabio
Bordignon, Claudio
Greenberg, Philip D
Holmes, Michael C
Gregory, Philip D
Naldini, Luigi
Bonini, Chiara
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5019824
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5019824
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.2700
