Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer
Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Brain metastasis represents a substantial source of morbidity and mortality in various cancers, and is characterized by high resistance to chemotherapy. Here we define the role of the most abundant cell type in the brain, the astrocyte, in promoting brain metastasis. We show that human and mouse breast and lung cancer cells express protocadherin 7...
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Full title
Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5021195
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5021195
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature18268
