Reg4⁺ deep crypt secretory cells function as epithelial niche for Lgr5⁺ stem cells in colon
Reg4⁺ deep crypt secretory cells function as epithelial niche for Lgr5⁺ stem cells in colon
About this item
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Author / Creator
Sasaki, Nobuo , Sachs, Norman , Wiebrands, Kay , Ellenbroek, Saskia I. J. , Fumagalli, Arianna , Lyubimova, Anna , Begthel, Harry , van den Born, Maaike , van Es, Johan H. , Karthaus, Wouter R. , Li, Vivian S. W. , López-Iglesias, Carmen , Peters, Peter J. , van Rheenen, Jacco , van Oudenaarden, Alexander and Clevers, Hans
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Leucine-rich repeat-containing G-protein coupled receptor 5-positive (Lgr5⁺) stem cells reside at crypt bottoms of the small and large intestine. Small intestinal Paneth cells supply Wnt3, EGF, and Notch signals to neighboring Lgr5⁺ stem cells. Whereas the colon lacks Paneth cells, deep crypt secretory (DCS) cells are intermingled with Lgr5⁺ stem c...
Alternative Titles
Full title
Reg4⁺ deep crypt secretory cells function as epithelial niche for Lgr5⁺ stem cells in colon
Authors, Artists and Contributors
Author / Creator
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5027439
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5027439
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1607327113
