Interleukin-21 promotes osteoclastogenesis in RAW264.7 cells through the PI3K/AKT signaling pathway...
Interleukin-21 promotes osteoclastogenesis in RAW264.7 cells through the PI3K/AKT signaling pathway independently of RANKL
About this item
Full title
Author / Creator
Xing, Rui , Zhang, Yingjian , Li, Changhong , Sun, Lin , Yang, Lin , Zhao, Jinxia and Liu, Xiangyuan
Publisher
Athens: D.A. Spandidos
Journal title
Language
English
Formats
Publication information
Publisher
Athens: D.A. Spandidos
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Scope and Contents
Contents
Cytokines play a key role in the bone destruction of rheumatoid arthritis (RA). Interleukin-21 (IL-21) promotes osteoclastogenesis in RA in a receptor activator of nuclear factor-κB ligand (RANKL)-dependent way. Whether IL-21 is capable of promoting osteoclastogenesis directly in the absence of RANKL remains unknown. In the present study, we examin...
Alternative Titles
Full title
Interleukin-21 promotes osteoclastogenesis in RAW264.7 cells through the PI3K/AKT signaling pathway independently of RANKL
Authors, Artists and Contributors
Author / Creator
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5029957
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5029957
Other Identifiers
ISSN
1107-3756
E-ISSN
1791-244X
DOI
10.3892/ijmm.2016.2722
