Mannose receptor induces T-cell tolerance via inhibition of CD45 and up-regulation of CTLA-4
Mannose receptor induces T-cell tolerance via inhibition of CD45 and up-regulation of CTLA-4
About this item
Full title
Author / Creator
Schuette, Verena , Embgenbroich, Maria , Ulas, Thomas , Welz, Meike , Schulte-Schrepping, Jonas , Draffehn, Astrid M. , Quast, Thomas , Koch, Katharina , Nehring, Melanie , König, Jessica , Zweynert, Annegret , Harms, Frederike L. , Steiner, Nancy , Limmer, Andreas , Förster, Irmgard , Berberich-Siebelt, Friederike , Knolle, Percy A. , Wohlleber, Dirk , Kolanus, Waldemar , Beyer, Marc , Schultze, Joachim L. and Burgdorf, Sven
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
The mannose receptor (MR) is an endocytic receptor involved in serum homeostasis and antigen presentation. Here, we identify the MR as a direct regulator of CD8⁺ T-cell activity. We demonstrate that MR expression on dendritic cells (DCs) impaired T-cell cytotoxicity in vitro and in vivo. This regulatory effect of the MR was mediated by a direct int...
Alternative Titles
Full title
Mannose receptor induces T-cell tolerance via inhibition of CD45 and up-regulation of CTLA-4
Authors, Artists and Contributors
Author / Creator
Embgenbroich, Maria
Ulas, Thomas
Welz, Meike
Schulte-Schrepping, Jonas
Draffehn, Astrid M.
Quast, Thomas
Koch, Katharina
Nehring, Melanie
König, Jessica
Zweynert, Annegret
Harms, Frederike L.
Steiner, Nancy
Limmer, Andreas
Förster, Irmgard
Berberich-Siebelt, Friederike
Knolle, Percy A.
Wohlleber, Dirk
Kolanus, Waldemar
Beyer, Marc
Schultze, Joachim L.
Burgdorf, Sven
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5035904
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5035904
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1605885113
