The rules and impact of nonsense-mediated mRNA decay in human cancers
The rules and impact of nonsense-mediated mRNA decay in human cancers
About this item
Full title
Author / Creator
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Ben Lehner and colleagues analyze data from matched exomes and transcriptomes from tumors across 27 cancer types to elucidate rules linking premature termination codon location to nonsense-mediated mRNA decay (NMD). They propose a model that explains variability in NMD efficiency and find evidence of positive and negative selection on NMD-initiatin...
Alternative Titles
Full title
The rules and impact of nonsense-mediated mRNA decay in human cancers
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5045715
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5045715
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/ng.3664
