Identifying lineage effects when controlling for population structure improves power in bacterial as...
Identifying lineage effects when controlling for population structure improves power in bacterial association studies
About this item
Full title
Author / Creator
Earle, Sarah G. , Wu, Chieh-Hsi , Charlesworth, Jane , Stoesser, Nicole , Gordon, N. Claire , Walker, Timothy M. , Spencer, Chris C. A. , Iqbal, Zamin , Clifton, David A. , Hopkins, Katie L. , Woodford, Neil , Smith, E. Grace , Ismail, Nazir , Llewelyn, Martin J. , Peto, Tim E. , Crook, Derrick W. , McVean, Gil , Walker, A. Sarah and Wilson, Daniel J.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Bacteria pose unique challenges for genome-wide association studies because of strong structuring into distinct strains and substantial linkage disequilibrium across the genome
1
,
2
. Although methods developed for human studies can correct for strain structure
3
,
4
, this risks considerable loss-of-power because genetic d...
Alternative Titles
Full title
Identifying lineage effects when controlling for population structure improves power in bacterial association studies
Authors, Artists and Contributors
Author / Creator
Wu, Chieh-Hsi
Charlesworth, Jane
Stoesser, Nicole
Gordon, N. Claire
Walker, Timothy M.
Spencer, Chris C. A.
Iqbal, Zamin
Clifton, David A.
Hopkins, Katie L.
Woodford, Neil
Smith, E. Grace
Ismail, Nazir
Llewelyn, Martin J.
Peto, Tim E.
Crook, Derrick W.
McVean, Gil
Walker, A. Sarah
Wilson, Daniel J.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5049680
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5049680
Other Identifiers
ISSN
2058-5276
E-ISSN
2058-5276
DOI
10.1038/nmicrobiol.2016.41
