Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-c...
Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models
About this item
Full title
Author / Creator
Svensson, Robert U , Parker, Seth J , Eichner, Lillian J , Kolar, Matthew J , Wallace, Martina , Brun, Sonja N , Lombardo, Portia S , Van Nostrand, Jeanine L , Hutchins, Amanda , Vera, Lilliana , Gerken, Laurie , Greenwood, Jeremy , Bhat, Sathesh , Harriman, Geraldine , Westlin, William F , Harwood, H James , Saghatelian, Alan , Kapeller, Rosana , Metallo, Christian M and Shaw, Reuben J
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
An allosteric inhibitor of acetyl-CoA carboxylase reveals a metabolic liability of non-small-cell lung cancer and slows tumor growth alone and in combination with chemotherapy in mouse models.
Continuous
de novo
fatty acid synthesis is a common feature of cancer that is required to meet the biosynthetic demands of a growing tumor. This pro...
Alternative Titles
Full title
Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models
Authors, Artists and Contributors
Author / Creator
Parker, Seth J
Eichner, Lillian J
Kolar, Matthew J
Wallace, Martina
Brun, Sonja N
Lombardo, Portia S
Van Nostrand, Jeanine L
Hutchins, Amanda
Vera, Lilliana
Gerken, Laurie
Greenwood, Jeremy
Bhat, Sathesh
Harriman, Geraldine
Westlin, William F
Harwood, H James
Saghatelian, Alan
Kapeller, Rosana
Metallo, Christian M
Shaw, Reuben J
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5053891
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5053891
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.4181
