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Biophysical determinants for cellular uptake of hydrocarbon-stapled peptide helices

Biophysical determinants for cellular uptake of hydrocarbon-stapled peptide helices

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5055751

Biophysical determinants for cellular uptake of hydrocarbon-stapled peptide helices

About this item

Full title

Biophysical determinants for cellular uptake of hydrocarbon-stapled peptide helices

Publisher

New York: Nature Publishing Group US

Journal title

Nature chemical biology, 2016-10, Vol.12 (10), p.845-852

Language

English

Formats

Publication information

Publisher

New York: Nature Publishing Group US

More information

Scope and Contents

Contents

Detailed biophysical, microscopy, and statistical analyses of hydrocarbon-stapled peptide variants revealed how a combination of critical parameters such as hydrophobicity, α-helicity and isoelectric point influence cellular permeability.
Hydrocarbon-stapled peptides are a class of bioactive alpha-helical ligands developed to dissect and target...

Alternative Titles

Full title

Biophysical determinants for cellular uptake of hydrocarbon-stapled peptide helices

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5055751

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5055751

Other Identifiers

ISSN

1552-4450

E-ISSN

1552-4469

DOI

10.1038/nchembio.2153

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