Acknowledgements This work was supported by the Priority Academic Program Development of Jiangsu Higher Education Institutions, Yangzhou, Jiangsu, People's Republic of China and a grant from the National Natural Science Foundation of China (No. 31272575). Authors' contributions CW, YS, RZ, and XX participated in the design of the study and wrote the manuscript. JJ, WS, WG, and YS participated in the design of the study and the collection of samples. RZ, JZ, KH, and YY performed the experiment. All authors read and approved the final manuscript. Competing interests The authors declare that they have no competing interests. Consent for publication Not applicable. Ethics approval and consent to participate The donors gave informed consent for their tissues and blood specimens to be used for research and the protocol was approved by the Institutional Review Board of Yangzhou University College of Medicine and the Human Tissue Oversight Committees in four hospitals. Collection of bovine blood specimens was approved by the Institutional Animal Care and Use Committee of Yangzhou University College of Veterinary Medicine. Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (