Oligodendrocytes contribute to motor neuron death in ALS via SOD1-dependent mechanism
Oligodendrocytes contribute to motor neuron death in ALS via SOD1-dependent mechanism
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Oligodendrocytes have recently been implicated in the pathophysiology of amyotrophic lateral sclerosis (ALS). Here we show that, in vitro, mutant superoxide dismutase 1 (SOD1) mouse oligodendrocytes induce WT motor neuron (MN) hyperexcitability and death. Moreover, we efficiently derived human oligodendrocytes from a large number of controls and pa...
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Full title
Oligodendrocytes contribute to motor neuron death in ALS via SOD1-dependent mechanism
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5081600
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5081600
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1607496113
