Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice
Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice
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Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
We describe a metabolic disorder characterized by lipodystrophy, hepatic steatosis, insulin resistance, severe diabetes, and growth retardation observed in mice carrying N-ethyl-N-nitrosourea (ENU)–induced mutations. The disorder was ascribed to a mutation of kelch repeat and BTB (POZ) domain containing 2 (Kbtbd2) and was mimicked by a CRISPR/Cas9-...
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Full title
Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5081616
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5081616
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1614467113
