Fluorofenidone attenuates pulmonary inflammation and fibrosis via inhibiting the activation of NALP3...
Fluorofenidone attenuates pulmonary inflammation and fibrosis via inhibiting the activation of NALP3 inflammasome and IL‐1β/IL‐1R1/MyD88/NF‐κB pathway
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Author / Creator
Song, Cheng , He, Lujuan , Zhang, Jin , Ma, Hong , Yuan, Xiangning , Hu, Gaoyun , Tao, Lijian , Zhang, Jian and Meng, Jie
Publisher
England: John Wiley and Sons Inc
Journal title
Language
English
Formats
Publication information
Publisher
England: John Wiley and Sons Inc
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Scope and Contents
Contents
Interleukin (IL)‐1β plays an important role in the pathogenesis of idiopathic pulmonary fibrosis. The production of IL‐1β is dependent upon caspase‐1‐containing multiprotein complexes called inflammasomes and IL‐1R1/MyD88/NF‐κB pathway. In this study, we explored whether a potential anti‐fibrotic agent fluorofenidone (FD) exerts its anti‐inflammato...
Alternative Titles
Full title
Fluorofenidone attenuates pulmonary inflammation and fibrosis via inhibiting the activation of NALP3 inflammasome and IL‐1β/IL‐1R1/MyD88/NF‐κB pathway
Authors, Artists and Contributors
Author / Creator
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5082399
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5082399
Other Identifiers
ISSN
1582-1838
E-ISSN
1582-4934
DOI
10.1111/jcmm.12898
