Notch3 drives development and progression of cholangiocarcinoma
Notch3 drives development and progression of cholangiocarcinoma
About this item
Full title
Author / Creator
Guest, Rachel V. , Boulter, Luke , Dwyer, Benjamin J. , Kendall, Timothy J. , Man, Tak-Yung , Minnis-Lyons, Sarah E. , Lu, Wei-Yu , Robson, Andrew J. , Gonzalez, Sofia Ferreira , Raven, Alexander , Wojtacha, Davina , Morton, Jennifer P. , Komuta, Mina , Roskams, Tania , Wigmore, Stephen J. , Sansom, Owen J. and Forbes, Stuart J.
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
The prognosis of cholangiocarcinoma (CC) is dismal. Notch has been identified as a potential driver; forced exogenous overexpression of Notch1 in hepatocytes results in the formation of biliary tumors. In human disease, however, it is unknown which components of the endogenously signaling pathway are required for tumorigenesis, how these orchestrat...
Alternative Titles
Full title
Notch3 drives development and progression of cholangiocarcinoma
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5086988
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5086988
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1600067113
