Addition of 20-kDa PEG to Insulin Lispro Alters Absorption and Decreases Clearance in Animals
Addition of 20-kDa PEG to Insulin Lispro Alters Absorption and Decreases Clearance in Animals
About this item
Full title
Author / Creator
Publisher
New York: Springer US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Springer US
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Scope and Contents
Contents
ABSTRACT
Purpose
Determine the pharmacokinetics of insulin peglispro (BIL) in 5/6-nephrectomized rats and study the absorption in lymph duct cannulated (LDC) sheep.
Methods
BIL is insulin lispro modified with 20-kDa linear PEG at lysine B28 increasing the hydrodynamic size to 4-fold larger than insulin lispro. Pharmacokinetics of BIL an...
Alternative Titles
Full title
Addition of 20-kDa PEG to Insulin Lispro Alters Absorption and Decreases Clearance in Animals
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5093203
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5093203
Other Identifiers
ISSN
0724-8741
E-ISSN
1573-904X
DOI
10.1007/s11095-016-2014-1
