Complement and microglia mediate early synapse loss in Alzheimer mouse models
Complement and microglia mediate early synapse loss in Alzheimer mouse models
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Publisher
United States: American Association for the Advancement of Science
Journal title
Language
English
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Publisher
United States: American Association for the Advancement of Science
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Scope and Contents
Contents
Synapse loss in Alzheimer's disease (AD) correlates with cognitive decline. Involvement of microglia and complement in AD has been attributed to neuroinflammation, prominent late in disease. Here we show in mouse models that complement and microglia mediate synaptic loss early in AD. C1q, the initiating protein of the classical complement cascade,...
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Full title
Complement and microglia mediate early synapse loss in Alzheimer mouse models
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5094372
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5094372
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aad8373
