Targeting methyltransferase PRMT5 eliminates leukemia stem cells in chronic myelogenous leukemia
Targeting methyltransferase PRMT5 eliminates leukemia stem cells in chronic myelogenous leukemia
About this item
Full title
Author / Creator
Jin, Yanli , Zhou, Jingfeng , Xu, Fang , Jin, Bei , Cui, Lijing , Wang, Yun , Du, Xin , Li, Juan , Li, Peng , Ren, Ruibao and Pan, Jingxuan
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
Imatinib-insensitive leukemia stem cells (LSCs) are believed to be responsible for resistance to BCR-ABL tyrosine kinase inhibitors and relapse of chronic myelogenous leukemia (CML). Identifying therapeutic targets to eradicate CML LSCs may be a strategy to cure CML. In the present study, we discovered a positive feedback loop between BCR-ABL and p...
Alternative Titles
Full title
Targeting methyltransferase PRMT5 eliminates leukemia stem cells in chronic myelogenous leukemia
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5096815
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5096815
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI85239
