Store-operated Ca2+ entry regulates Ca2+-activated chloride channels and eccrine sweat gland functio...
Store-operated Ca2+ entry regulates Ca2+-activated chloride channels and eccrine sweat gland function
About this item
Full title
Author / Creator
Concepcion, Axel R. , Vaeth, Martin , Wagner, Larry E. , Eckstein, Miriam , Hecht, Lee , Yang, Jun , Crottes, David , Seidl, Maximilian , Shin, Hyosup P. , Weidinger, Carl , Cameron, Scott , Turvey, Stuart E. , Issekutz, Thomas , Meyts, Isabelle , Lacruz, Rodrigo S. , Cuk, Mario , Yule, David I. and Feske, Stefan
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
Eccrine sweat glands are essential for sweating and thermoregulation in humans. Loss-of-function mutations in the Ca2+ release-activated Ca2+ (CRAC) channel genes ORAI1 and STIM1 abolish store-operated Ca2+ entry (SOCE), and patients with these CRAC channel mutations suffer from anhidrosis and hyperthermia at high ambient temperatures. Here we have...
Alternative Titles
Full title
Store-operated Ca2+ entry regulates Ca2+-activated chloride channels and eccrine sweat gland function
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5096923
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5096923
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI89056
