Novel method to rescue a lethal phenotype through integration of target gene onto the X-chromosome
Novel method to rescue a lethal phenotype through integration of target gene onto the X-chromosome
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The loss-of-function mutations of serine protease inhibitor, Kazal type 1 (
SPINK1
) gene are associated with human chronic pancreatitis, but the underlying mechanisms remain unknown. We previously reported that mice lacking
Spink3
, the murine homologue of human
SPINK1
, die perinatally due to massive pancreatic acinar cell death...
Alternative Titles
Full title
Novel method to rescue a lethal phenotype through integration of target gene onto the X-chromosome
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5109027
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5109027
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/srep37200
