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Recurrent somatic mutations in POLR2A define a distinct subset of meningiomas

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Recurrent somatic mutations in POLR2A define a distinct subset of meningiomas

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5114141

Recurrent somatic mutations in POLR2A define a distinct subset of meningiomas

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New York: Nature Publishing Group US

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Contents

Murat Günel and colleagues identify recurrent mutations in
POLR2A
, which encodes the catalytic subunit of RNA polymerase II, in a subset of meningiomas. They find that
POLR2A
-mutant tumors can be distinguished on the basis of their super-enhancer and gene expression profiles, which show dysregulation of key meningeal identity genes.

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Recurrent somatic mutations in POLR2A define a distinct subset of meningiomas

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Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5114141

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5114141

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ISSN

1061-4036

E-ISSN

1546-1718

DOI

10.1038/ng.3651

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