Discovery of MRSA active antibiotics using primary sequence from the human microbiome
Discovery of MRSA active antibiotics using primary sequence from the human microbiome
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Author / Creator
Chu, John , Vila-Farres, Xavier , Inoyama, Daigo , Ternei, Melinda , Cohen, Louis J , Gordon, Emma A , Reddy, Boojala Vijay B , Charlop-Powers, Zachary , Zebroski, Henry A , Gallardo-Macias, Ricardo , Jaskowski, Mark , Satish, Shruthi , Park, Steven , Perlin, David S , Freundlich, Joel S and Brady, Sean F
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
The synthetic bioinformatic natural products (syn-BNPs) approach identifies putative natural products that are validated directly by independent synthesis. Its application led to the identification of humimycins, non-ribosomal peptides that have antimicrobial activity in mice.
Here we present a natural product discovery approach, whereby structu...
Alternative Titles
Full title
Discovery of MRSA active antibiotics using primary sequence from the human microbiome
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5117632
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5117632
Other Identifiers
ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/nchembio.2207
