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Structural basis for precursor protein–directed ribosomal peptide macrocyclization

Structural basis for precursor protein–directed ribosomal peptide macrocyclization

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5117808

Structural basis for precursor protein–directed ribosomal peptide macrocyclization

About this item

Full title

Structural basis for precursor protein–directed ribosomal peptide macrocyclization

Publisher

New York: Nature Publishing Group US

Journal title

Nature chemical biology, 2016-11, Vol.12 (11), p.973-979

Language

English

Formats

Publication information

Publisher

New York: Nature Publishing Group US

More information

Scope and Contents

Contents

Biosynthesis of the protease inhibitor microviridin J includes peptide macrocyclization catalyzed by two enzymes of the ATP-grasp family. Structures of these macrocyclases, MdnB and MdnC, reveal how they recognize their precursor-peptide substrates.
Macrocyclization is a common feature of natural product biosynthetic pathways including the diver...

Alternative Titles

Full title

Structural basis for precursor protein–directed ribosomal peptide macrocyclization

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5117808

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5117808

Other Identifiers

ISSN

1552-4450

E-ISSN

1552-4469

DOI

10.1038/nchembio.2200

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