Structural basis for precursor protein–directed ribosomal peptide macrocyclization
Structural basis for precursor protein–directed ribosomal peptide macrocyclization
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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Contents
Biosynthesis of the protease inhibitor microviridin J includes peptide macrocyclization catalyzed by two enzymes of the ATP-grasp family. Structures of these macrocyclases, MdnB and MdnC, reveal how they recognize their precursor-peptide substrates.
Macrocyclization is a common feature of natural product biosynthetic pathways including the diver...
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Full title
Structural basis for precursor protein–directed ribosomal peptide macrocyclization
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5117808
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5117808
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ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/nchembio.2200