Growth factor and co-receptor release by structural regulation of substrate metalloprotease accessib...
Growth factor and co-receptor release by structural regulation of substrate metalloprotease accessibility
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Release of cytokines, growth factors and other life-essential molecules from precursors by a-disintegrin-and-metalloproteases (ADAMs) is regulated with high substrate-specificity. We hypothesized that this is achieved by cleavage-regulatory intracellular-domain (ICD)-modifications of the precursors. We show here that cleavage-stimuli-induced specif...
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Full title
Growth factor and co-receptor release by structural regulation of substrate metalloprotease accessibility
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5120278
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5120278
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/srep37464
