Mevalonate kinase deficiency leads to decreased prenylation of Rab GTPases
Mevalonate kinase deficiency leads to decreased prenylation of Rab GTPases
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Publisher
England: Nature Publishing Group
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Language
English
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Publisher
England: Nature Publishing Group
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Scope and Contents
Contents
Mevalonate kinase deficiency (MKD) is caused by mutations in a key enzyme of the mevalonate–cholesterol biosynthesis pathway, leading to recurrent autoinflammatory disease characterised by enhanced release of interleukin‐1β (IL‐1β). It is currently believed that the inflammatory phenotype of MKD is triggered by temperature‐sensitive loss of mevalon...
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Full title
Mevalonate kinase deficiency leads to decreased prenylation of Rab GTPases
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5122740
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5122740
Other Identifiers
ISSN
0818-9641
E-ISSN
1440-1711
DOI
10.1038/icb.2016.58
