Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease
Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease
About this item
Full title
Author / Creator
Hyslop, Louise A. , Blakeley, Paul , Craven, Lyndsey , Richardson, Jessica , Fogarty, Norah M. E. , Fragouli, Elpida , Lamb, Mahdi , Wamaitha, Sissy E. , Prathalingam, Nilendran , Zhang, Qi , O’Keefe, Hannah , Takeda, Yuko , Arizzi, Lucia , Alfarawati, Samer , Tuppen, Helen A. , Irving, Laura , Kalleas, Dimitrios , Choudhary, Meenakshi , Wells, Dagan , Murdoch, Alison P. , Turnbull, Douglass M. , Niakan, Kathy K. and Herbert, Mary
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Preclinical evaluation and optimization of mitochondrial replacement therapy reveals that a modified form of pronuclear transfer is likely to give rise to normal pregnancies with a reduced risk of mitochondrial DNA disease, but may need further modification to eradicate the disease in all cases.
Mitochondria replacement by pronuclear transfer
Alternative Titles
Full title
Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease
Authors, Artists and Contributors
Author / Creator
Blakeley, Paul
Craven, Lyndsey
Richardson, Jessica
Fogarty, Norah M. E.
Fragouli, Elpida
Lamb, Mahdi
Wamaitha, Sissy E.
Prathalingam, Nilendran
Zhang, Qi
O’Keefe, Hannah
Takeda, Yuko
Arizzi, Lucia
Alfarawati, Samer
Tuppen, Helen A.
Irving, Laura
Kalleas, Dimitrios
Choudhary, Meenakshi
Wells, Dagan
Murdoch, Alison P.
Turnbull, Douglass M.
Niakan, Kathy K.
Herbert, Mary
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5131843
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5131843
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature18303
