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Disentangling the roles of cholesterol and CD59 in intermedilysin pore formation

Disentangling the roles of cholesterol and CD59 in intermedilysin pore formation

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5133593

Disentangling the roles of cholesterol and CD59 in intermedilysin pore formation

About this item

Full title

Disentangling the roles of cholesterol and CD59 in intermedilysin pore formation

Publisher

London: Nature Publishing Group UK

Journal title

Scientific reports, 2016-12, Vol.6 (1), p.38446-38446, Article 38446

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

The plasma membrane provides an essential barrier, shielding a cell from the pressures of its external environment. Pore-forming proteins, deployed by both hosts and pathogens alike, breach this barrier to lyse target cells. Intermedilysin is a cholesterol-dependent cytolysin that requires the human immune receptor CD59, in addition to cholesterol,...

Alternative Titles

Full title

Disentangling the roles of cholesterol and CD59 in intermedilysin pore formation

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5133593

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5133593

Other Identifiers

ISSN

2045-2322

E-ISSN

2045-2322

DOI

10.1038/srep38446

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