Metformin protects against apoptosis and senescence in nucleus pulposus cells and ameliorates disc d...
Metformin protects against apoptosis and senescence in nucleus pulposus cells and ameliorates disc degeneration in vivo
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Intervertebral disc degeneration (IDD) is a complicated process that involves both cellular apoptosis and senescence. Metformin has been reported to stimulate autophagy, whereas autophagy is shown to protect against apoptosis and senescence. Therefore, we hypothesize that metformin may have therapeutic effect on IDD through autophagy stimulation. T...
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Full title
Metformin protects against apoptosis and senescence in nucleus pulposus cells and ameliorates disc degeneration in vivo
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5133996
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5133996
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ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/cddis.2016.334
