The protective role of MLCP-mediated ERM dephosphorylation in endotoxin-induced lung injury in vitro...
The protective role of MLCP-mediated ERM dephosphorylation in endotoxin-induced lung injury in vitro and in vivo
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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The goal of this study was to investigate the role of MLC phosphatase (MLCP) in a LPS model of acute lung injury (ALI). We demonstrate that ectopic expression of a constitutively-active (C/A) MLCP regulatory subunit (MYPT1) attenuates the ability of LPS to increase endothelial (EC) permeability. Down-regulation of MYPT1 exacerbates LPS-induced expr...
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Full title
The protective role of MLCP-mediated ERM dephosphorylation in endotoxin-induced lung injury in vitro and in vivo
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5157034
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5157034
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/srep39018
