PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insuli...
PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance
About this item
Full title
Author / Creator
Publisher
American Society for Clinical Investigation
Journal title
Language
English
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Publication information
Publisher
American Society for Clinical Investigation
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Scope and Contents
Contents
Inadequate compensatory β cell hyperplasia in insulin-resistant states triggers the development of overt diabetes. The mechanisms that underlie this crucial adaptive response are not fully defined. Here we show that the compensatory islet-growth response to insulin resistance in 2 models — insulin receptor (IR)/IR substrate–1 (IRS-1) double heteroz...
Alternative Titles
Full title
PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_516265
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_516265
Other Identifiers
ISSN
0021-9738
DOI
10.1172/JCI200421845
