PTEN opposes negative selection and enables oncogenic transformation of pre-B cells
PTEN opposes negative selection and enables oncogenic transformation of pre-B cells
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Author / Creator
Shojaee, Seyedmehdi , Chan, Lai N , Buchner, Maike , Cazzaniga, Valeria , Cosgun, Kadriye Nehir , Geng, Huimin , Qiu, Yi Hua , von Minden, Marcus Dühren , Ernst, Thomas , Hochhaus, Andreas , Cazzaniga, Giovanni , Melnick, Ari , Kornblau, Steven M , Graeber, Thomas G , Wu, Hong , Jumaa, Hassan and Müschen, Markus
Publisher
New York: Nature Publishing Group US
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English
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Publisher
New York: Nature Publishing Group US
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Contents
As opposed to its tumor suppressor role in other cancers, PTEN inhibition in pre-B ALL is therapeutically effective and triggers cell death.
Phosphatase and tensin homolog (PTEN) is a negative regulator of the phosphatidylinositol 3-kinase (PI3K) and protein kinase B (AKT) signaling pathway and a potent tumor suppressor in many types of cancer....
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Full title
PTEN opposes negative selection and enables oncogenic transformation of pre-B cells
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5178869
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5178869
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.4062
