Blocking type I interferon signaling enhances T cell recovery and reduces HIV-1 reservoirs
Blocking type I interferon signaling enhances T cell recovery and reduces HIV-1 reservoirs
About this item
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Author / Creator
Cheng, Liang , Ma, Jianping , Li, Jingyun , Li, Dan , Li, Guangming , Li, Feng , Zhang, Qing , Yu, Haisheng , Yasui, Fumihiko , Ye, Chaobaihui , Tsao, Li-Chung , Hu, Zhiyuan , Su, Lishan and Zhang, Liguo
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
Despite the efficient suppression of HIV-1 replication that can be achieved with combined antiretroviral therapy (cART), low levels of type I interferon (IFN-I) signaling persist in some individuals. This sustained signaling may impede immune recovery and foster viral persistence. Here we report studies using a monoclonal antibody to block IFN-α/β...
Alternative Titles
Full title
Blocking type I interferon signaling enhances T cell recovery and reduces HIV-1 reservoirs
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5199717
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5199717
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI90745
