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Loss-of-function genetic tools for animal models: cross-species and cross-platform differences

Loss-of-function genetic tools for animal models: cross-species and cross-platform differences

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5206767

Loss-of-function genetic tools for animal models: cross-species and cross-platform differences

About this item

Full title

Loss-of-function genetic tools for animal models: cross-species and cross-platform differences

Publisher

London: Nature Publishing Group UK

Journal title

Nature reviews. Genetics, 2017-01, Vol.18 (1), p.24-40

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Key Points
Loss-of-function (LOF) technologies are widely used across many model organisms and many fields.
Although all LOF approaches have the shared goal of perturbing gene function, there are complex differences between approaches that can have a considerable effect on the outcome of experiments.
The specific properties and effect of e...

Alternative Titles

Full title

Loss-of-function genetic tools for animal models: cross-species and cross-platform differences

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5206767

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5206767

Other Identifiers

ISSN

1471-0056

E-ISSN

1471-0064

DOI

10.1038/nrg.2016.118

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