HIV-1 Env associates with HLA-C free-chains at the cell membrane modulating viral infectivity
HIV-1 Env associates with HLA-C free-chains at the cell membrane modulating viral infectivity
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Author / Creator
Serena, Michela , Parolini, Francesca , Biswas, Priscilla , Sironi, Francesca , Blanco Miranda, Almudena , Zoratti, Elisa , Scupoli, Maria Teresa , Ziglio, Serena , Valenzuela-Fernandez, Agustin , Gibellini, Davide , Romanelli, Maria Grazia , Siccardi, Antonio , Malnati, Mauro , Beretta, Alberto and Zipeto, Donato
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
HLA-C has been demonstrated to associate with HIV-1 envelope glycoprotein (Env). Virions lacking HLA-C have reduced infectivity and increased susceptibility to neutralizing antibodies. Like all others MHC-I molecules, HLA-C requires β
2
-microglobulin (β
2
m) for appropriate folding and expression on the cell membrane but this associati...
Alternative Titles
Full title
HIV-1 Env associates with HLA-C free-chains at the cell membrane modulating viral infectivity
Authors, Artists and Contributors
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5209703
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5209703
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/srep40037
