DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer
DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer
About this item
Full title
Author / Creator
Mateo, Joaquin , Carreira, Suzanne , Sandhu, Shahneen , Miranda, Susana , Mossop, Helen , Perez-Lopez, Raquel , Nava Rodrigues, Daniel , Robinson, Dan , Omlin, Aurelius , Tunariu, Nina , Boysen, Gunther , Porta, Nuria , Flohr, Penny , Gillman, Alexa , Figueiredo, Ines , Paulding, Claire , Seed, George , Jain, Suneil , Ralph, Christy , Protheroe, Andrew , Hussain, Syed , Jones, Robert , Elliott, Tony , McGovern, Ursula , Bianchini, Diletta , Goodall, Jane , Zafeiriou, Zafeiris , Williamson, Chris T , Ferraldeschi, Roberta , Riisnaes, Ruth , Ebbs, Bernardette , Fowler, Gemma , Roda, Desamparados , Yuan, Wei , Wu, Yi-Mi , Cao, Xuhong , Brough, Rachel , Pemberton, Helen , A’Hern, Roger , Swain, Amanda , Kunju, Lakshmi P , Eeles, Rosalind , Attard, Gerhardt , Lord, Christopher J , Ashworth, Alan , Rubin, Mark A , Knudsen, Karen E , Feng, Felix Y , Chinnaiyan, Arul M , Hall, Emma and de Bono, Johann S
Publisher
United States: Massachusetts Medical Society
Journal title
Language
English
Formats
Publication information
Publisher
United States: Massachusetts Medical Society
Subjects
More information
Scope and Contents
Contents
Fourteen of 16 patients with metastatic, castration-resistant prostate cancer and genetic defects in repair of DNA damage had a response to the PARP inhibitor olaparib. Anemia and fatigue were the major toxic effects.
Prostate cancer is the most common cancer in men and the sixth leading cause of death from cancer among men throughout the world....
Alternative Titles
Full title
DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer
Authors, Artists and Contributors
Author / Creator
Carreira, Suzanne
Sandhu, Shahneen
Miranda, Susana
Mossop, Helen
Perez-Lopez, Raquel
Nava Rodrigues, Daniel
Robinson, Dan
Omlin, Aurelius
Tunariu, Nina
Boysen, Gunther
Porta, Nuria
Flohr, Penny
Gillman, Alexa
Figueiredo, Ines
Paulding, Claire
Seed, George
Jain, Suneil
Ralph, Christy
Protheroe, Andrew
Hussain, Syed
Jones, Robert
Elliott, Tony
McGovern, Ursula
Bianchini, Diletta
Goodall, Jane
Zafeiriou, Zafeiris
Williamson, Chris T
Ferraldeschi, Roberta
Riisnaes, Ruth
Ebbs, Bernardette
Fowler, Gemma
Roda, Desamparados
Yuan, Wei
Wu, Yi-Mi
Cao, Xuhong
Brough, Rachel
Pemberton, Helen
A’Hern, Roger
Swain, Amanda
Kunju, Lakshmi P
Eeles, Rosalind
Attard, Gerhardt
Lord, Christopher J
Ashworth, Alan
Rubin, Mark A
Knudsen, Karen E
Feng, Felix Y
Chinnaiyan, Arul M
Hall, Emma
de Bono, Johann S
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5228595
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5228595
Other Identifiers
ISSN
0028-4793
E-ISSN
1533-4406
DOI
10.1056/NEJMoa1506859
